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RESEARCH AND DEVELOPMENT

Research & Development is the key driver of Lupin’s success.

The Company invested about 8.7% of its net sales in R&D and related spends, amounting to Rs.10, 988 million in FY15.

Headquartered at the state-of-the-art Lupin Research Park (LRP) in Pune, India & home to 240+ dedicated scientists working on API Development at all times.

Each development initiated at R & D is carefully evaluated at each level so as to present an API with the best process possible while allowing earliest possible market entry to our customers.

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Process Development:
  • IP Driven Development
  • QbD/DoE
  • Genotoxic Evaluation & Control

Sourcing/ Vendor Development :
  • Leveraging Established China Sourcing for Timely identification & availability of Intermediates
  • Assisting in creating right TDP at the early stage of development
  • Exhaustive impurity profiling of KSM and intermediates for faster approvability

Cost Competitiveness by:
  • Robust optimized, well studied processes
  • Strong benchmarking with competition to target right cost
  • Backward integrated wherever necessary

Process Engineering:
  • Team to study process safety issues & Engineering for Robustness of process
  • Developing safe/scalable process through sound piloting studies/ process engineering
  • Well equipped Kilo Lab (cGMP) to study and sort out anticipated scale-up issues
Synthetic Chemistry
Lupin’s facility is equipped to carry out synthesis of molecules with complex chemistry.
Vertical integration – making intermediates & API guarantees products in line with the quality associated with Lupin.
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Fermentation
Lupin’s legacy with fermentation products combined with continuous innovation has made Lupin a trusted name in the industry.
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High Potency Development
Established skills in handling high potency APIs
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Customization
Lupin can provide API which fit customer’s specifications – in terms of Polymorph development & physical properties
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Lupin’s facility is equipped to carry out synthesis of molecules with complex chemistry.

Vertical integration – making intermediates & API guarantees products in line with the quality associated with Lupin.

Established skills in undertaking development of diverse therapeutic categories
Developing processes involving
− Complex Chemistry
− Multistep Synthesis
− Enantio Selective/ Diastereo Selective Synthesis
− Complex separation techniques
− Green Chemistry

Lupin’s legacy with fermentation products combined with continuous innovation has made Lupin a trusted name in the industry.

The production of APIs via fermentation is one of Lupin’s core competencies.

Lupin’s expertise in Fermentation is derived from decades of experience in developing and producing fermentation products across different scales supported by multipurpose downstream plants for product isolation, and purification.

Established skills in handling high potency APIs.

Established skills in undertaking development of diverse Therapeutic categories & capability in handling HP APIs
− Prostaglandin
− Hormones / Steroids
− Oncology APIs (coming soon)

Lupin can provide API which fit customer’s specifications – in terms of Polymorph development & physical properties

At Lupin, you can consistently get the right kind of product which fits your development and commercial requirements

Dedicated group working on polymorphism/crystal engineering & physical characteristics helps in delivering customized API of the desired nature:
− Stabilized Polymorph
− Particle size
− Bulk Density, Tap Density
− Aspect ratio
− Crystal size & shape